SCIENCE & DEVELOPMENT

Awakening of dormant follicles to become fertile eggs

iNotify focuses on the activation of so-called dormant follicles –  a process that is pivotal for fertile eggs to mature. This early phase of follicle development is independent of hormones, and thus fundamentally different from the hormone-dependent processes that characterize the late maturation phase.    

To activate dormant follicles, iNotify targets the intracellular AKT pathway; a promotor of survival and growth and a major driver of follicle activation. iNotify has identified and validated a compound that activates the AKT pathway in a controlled manner and thus supports the activation and ‘waking up’ of dormant follicles. 

In vitro and ex vivo proof-of-concept has been established. The identified compound has demonstrated activity in ex vivo ovarian tissue from infertile patients and in ovaries isolated from old female mice (a model of low ovarian reserves).

Preliminary non-GLP toxicological studies have demonstrated a very good safety profile.

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Target Product profile

Indication

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Active drug

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Formulation

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Equipment

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Developmental stage

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Route of approval

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Development / Our science

Awakening of dormant follicles to become fertile eggs.

iNotify focuses on the activation of so-called dormant follicles –  a process that is pivotal for fertile eggs to mature. This early phase of follicle development is independent of hormones, and thus fundamentally different from the hormone-dependent processes that characterize the late maturation phase.    

To activate dormant follicles, iNotify targets the intracellular AKT pathway; a promotor of survival and growth and a major driver of follicle activation. iNotify has identified and validated a compound that activates the AKT pathway in a controlled manner and thus supports the activation and ‘waking up’ of dormant follicles. 

In vitro and ex vivo proof-of-concept has been established. The identified compound has demonstrated activity in ex vivo ovarian tissue from infertile patients and in ovaries isolated from old female mice (a model of low ovarian reserves).

Preliminary non-GLP toxicological studies have demonstrated a very good safety profile.

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